Intravenous compatibility chart acyclovir acyclovir. Intravenous anesthetic agents instructional resources. Compatibility of propofol injection with the coadministration of bloodserumplasma has. Remifentanil hydrochloride monograph for professionals. We strove to evaluate and present the available published data as a comprehensive and practical reference. Propofol injectable emulsion should not be coadministered through the same iv catheter with blood or plasma because compatibility has not been established. Elsevier compatibility of propofol, fentanyl, and vecuronium mixtures designed for potential use in anesthesia and patient transport peter r. Diprivan propofol dosing, indications, interactions. Propofol is an intravenous iv sedativehypnotic agent that can be used for initiation and maintenance of monitored anesthesia care sedation, combined sedation and regional anesthesia, induction of general anesthesia, maintenance of general anesthesia, and intensive care unit sedation of intubated, mechanically ventilated patients.
Propofol compatibility with other intravenous drug productstwo new methods of evaluating iv emulsion compatibility. To prepare the infusion, withdraw 2 ml of precedex and add to 48 ml of 0. Propofol remifentanil milrinone morphine noradrenaline omeprazole thiopental vancomycin vasopressin arginine vasopressin rocuronium salbutamol sodium bicarbonate sodium chloride 0. In addition, scanning electron microscopy was used to determine the maximum detectable droplet size in randomly selected fields. Propofol injectable emulsionis a singleuse parenteral product which contains benzyl alcohol 1. Increase dose in patients with chronic alcoholism fassoulaki, 1993. Ysite compatibility of medications with parenteral nutrition. Propofol is an intravenous iv sedativehypnotic agent that can be used for initiation and maintenance of monitored anesthesia care sedation, combined sedation and regional anesthesia, induction of general anesthesia, maintenance of general anesthesia, and intensive care unit sedation of intubated, mechanically ventilated patients propofol is available under the following different brand. Propofol is slightly soluble in water and, thus, is formulated in a white, oilinwater. The prescriber is responsible for the verification of indications and dosages listed in the manufacturers package insert for the individual drugs, from which most information for this dosing guide is obtained. Pdf propofolcompatible plastics or plasticcompatible propofol.
Propofol is not water soluble, and is prepared as a milky white emulsion of containing 10. Cardiac anesthesia propofol was evaluated in 328 patients undergoing coronary artery bypass graft cabg. Pdf propofol is an intravenous hypnotic drug that is used for induction and maintenance of sedation and general anaesthesia. Patients with hepatic or renal impairmesevere nt have not been adequately studied. An investigation of the pharmacokinetic profile of propofol diprivan after administration for induction and maintenance of anaesthesia by repeat bolus doses in patients having spinal anaesthetic block. Thames valley ysite intravenous drugs compatibility chart. Maintenance2575 mcgkgmin infusion or incremental bolusesof1020mg. You can publish your book online for free in a few minutes. Iv ysite drugincompatibility dataa incompatible drugs avoid ysite administration with zosyn variable compatibility acyclovir amiodarone hcl amphotericin b caspofungin chlorpromazine cisplatin daunorubicin decarbazine dobutamine doxorubicin doxycycline droperidol famotidine ganciclovir gemcitabine haloperidol hydroxyzine idarubicin mitomycin. It is extensively metabolized, with most of the administered dose appearing.
Iv drug compatibility chart the iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Currently there are multiple resources to use when answering the question of compatibility with parenteral nutrition. Iv geriatric patients, debilitated patients, or asa iii iv patients. To reduce pain associated with injection, use larger veins of forearm or antecubital fossa.
Objectives the purpose of this study was the determination of the physicochemical compatibility and emulsion stability of propofol with other sedatives and analgesics clonidine hydrochloride, dexmedetomidine, 4hydroxybutyric acid, s ketamine, lormetazepam, midazolam hydrochloride, piritramide, remifentanil hydrochloride and sufentanil citrate that are frequently. Propofol is commonly paired with fentanyl for pain relief in intubated and sedated people. The system learns from interaction with users and will be able to answer more sophisticated questions over time. Watson is in medical residency and can answer many drug information questions. Propofol is very commonly used in the icu as a sedation medication for intubated people. Remifentanil compared with alfentanil for ambulatory surgery. Ysite injection drug compatibility chart for critical. Propofolii injection should not be coadministered through the same i. Remifentanil compared with alfentanil for ambulatory. Physicochemical compatibility and emulsion stability of. Propofol injectable emulsion for iv administration prescribing.
The pharmacokinetics of propofol are linear over the recommended range of infusion rates of diprivan. Find patient medical information for propofol intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Diprivan propofol injectable emulsion is a sterile, nonpyrogenic emulsion containing 10 mgml of propofol suitable for intravenous administration. Of these patients 85% were males mean age 61, range 3283 and 15% were females mean age 65, range 4286. Compatibility of propofol, fentanyl, and vecuronium mixtures. Trissel, fashp, 2010, american society of healthsystem pharmacists.
Intravenous compatibility chart drug information for the. Mar 05, 2020 propofol injectable emulsion should not be coadministered through the same iv catheter with blood or plasma because compatibility has not been established. In vitro tests have shown that aggregates of the globular component of the emulsion vehicle have occurred with bloodplasmaserum from humans and animals. Propofol compatibility with other intravenous drug products. The anesthesia sequence was propofol 2 mgkg intravenously iv followed by 150 pg kg minl, and either remifentanil 1 pgkg iv followed by 0. Propofol is chemically described as 2,6diisopropylphenol and has a molecular weight of 178. Published data may report both compatibility and stability, however most evaluate compatibility alone. Compatibility depends upon many factors including temperature, ph, iv fluid, concentration, order of mixing and brand of drug. Capitals indicate lifethreatening, underlines indicate most frequent. Diprivan propofol dose, indications, adverse effects. Moderate hepatic or renal impairment do not alter these pharmacokinetics. Jan 18, 2017 strict aseptic technique must always be maintained during handling.
Physicochemical compatibility of propofollidocaine mixture. May be diluted in dextrose, saline, ringers solution, lr, dextrosesaline, dextroseringers solution, and dextroselr combinations. Intravenous compatibility chart drug information for. Propofol compatibility with other intravenous drug productstwo new methods of evaluating iv emulsion compatibility michele r michaels, gene l stauffer, and daniel p haas annals of pharmacotherapy 1996 30.
Iv ysite infusion solutioncompatibility data infusion solution compatible. Information in this booklet should be used as a guide only. Pdf clinical pharmacokinetics and pharmacodynamics of propofol. Elsevier international journal of pharmaceutics 127 1996 255259 international journal of pharmaceutics medical plastics. Diprivan injectable emulsion is a singleuse parenteral product which contains 0. Diprivan is an intravenous general anesthetic and sedation drug for use in the induction. Drug name administration dosing instruction how to titrate monitoringother information nicardipine 2mg2ml max conc. To determine the physicalcompatibility of propofol injection. Strict aseptic technique must always be maintained during handling. Propofol, valproic acid, phenytoin, theophylline, methylprednisolone and furosemide were also incompatible, whereas ketamine, sufentanil, midazolam, morphine, piritramide, nicardipine, urapidil, dopamine, dobutamine and adrenaline were compatible. Kennedy, bpharm, phd division of anesthesia and intensive care, the prince of wales hospital, randwick, new south wales, australia, and the. Compatibility of propofol, fentanyl, and vecuronium. Ysite injection drug compatibility chart for critical care wards.
Stability and compatibility of vancomycin for administration. It can be run through a peripheral iv or central line. Propofol is a nonbarbiturate, nondissociative intravenous anesthetic agent, and very widely used in dogs and cats. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Diprivan propofol injectable emulsion for iv administration strict aseptic technique must always be maintained during handling.
Iv geriatric patients, debilitated patients, or asa iiiiv patients. Stability of ketaminepropofol mixtures for procedural. Propofol 2,6diisopropylphenol is becoming the intravenous anesthetic of choice for ambulatory surgery in outpatients. Following a single iv injection, onset as determined by time to unconsciousness i. Administration into a running intravenous catheter. After iv administration of propofol, loss of consciousness usually occurs within 40 seconds, although the onset of action varies with the dose, rate of administration, and extent of premedication. Objectives the purpose of this study was the determination of the physicochemical compatibility and emulsion stability of propofol with other sedatives and analgesics clonidine hydrochloride, dexmedetomidine, 4hydroxybutyric acid, s ketamine, lormetazepam, midazolam hydrochloride, piritramide, remifentanil hydrochloride and sufentanil citrate that are frequently administered together. The objective was to evaluate the effectiveness, recovery time, and adverse event profile of intravenous iv mixed 1. Macroscopically, separate, colorless layers were first seen at 3 and 24 h after the addition of 40 and 20 mg of lidocaine to propofol, respectively, whereas the mixture with 5 or 10 mg of lidocaine was. Incompatibility of propofol emulsion with anesthetic drugs. Propofol diprivan and clevidipine cleviprex and potential lookalike concern propofol diprivan is an intravenous iv sedative agent used in the induction and maintenance of general anesthesia, monitored anesthesia care sedation, procedural sedation, and sedation for mechanical ventilation see figure 1. Propofolii injection is used in conjunction with other agents likely to cause a bradycardia. Risk of muscle rigidity is related to the dose and rate of iv administration.
Propofol is chemically described as 2,6diisopropylphenol. Isert, mb, bs, fanzca, doris lee, bsc,f daya naidoo, mbchb, frcpa, md,f melanie l. Propofol should not be coadministered through the same i. Ysite injection drug compatibility chart for critical care wards key to symbols. Propofol compatibility with other intravenous drug. No effect or incompatibility with nacetylcysteine or amino acid solutions was detected.
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